Although there are numerous benefits associated with using Effexor as a treatment for anxiety, it is clearly not a utopian anxiolytic for all users. Various drawbacks associated with Effexor usage include: long-term effects, unwanted side effects, unsustainable efficacy, and/or a possible worsening of anxiety. Though the benefits may significantly outweigh the drawbacks for many users, others will derive no anxiolytic benefit from Effexor. You, as a reader of this website, are totally and completely responsible for your own health and healthcare. 2001: Venlafaxine extended release (ER) in the treatment of generalized anxiety disorder: twenty-four-week placebo-controlled dose-ranging study. Effexor (Venlafaxine) is a drug that was introduced in 1993 as a pharmaceutical antidepressant by Wyeth; its marketing rights are now owned by Pfizer. Pharmacodynamically, it functions primarily as a serotonin-norepinephrine reuptake inhibitor (SNRI) and is understood to be the first-ever âdual reuptake inhibitorâ approved by the FDA for the treatment of major depressive disorder. Unlike selective-serotonin reuptake inhibitors (SSRIs) which solely modify serotonin levels, Effexor simultaneously increases extracellular levels of both serotonin and norepinephrine. In 2007, a report published by Kjernisted and McIntosh documented the efficacy of Effexor XR as an antipanic agent. Researchers noted that Effexor XR appears to effectively reduce panic attacks among those diagnosed with panic disorder, regardless of whether administered over a short or long-term. They also mentioned that in 12-week trials, Effexor XR was superior in efficacy to a placebo in facilitation of a âpanic-freeâ state. If symptoms last more than a few months, it may be PTSD. Different individuals may respond to medication in different ways. Although the odds are technically in your favor that Effexor will improve an anxiety disorder (as supported by the research), favorable odds don’t equal universal efficacy and tolerability. Worked against sluggish cognitive tempo and being able to keep more than one number, or variable in the head. There are four SSRIs/SNRIs that are recommended for PTSD: Sertraline (Zoloft) Paroxetine (Paxil) Fluoxetine (Prozac) Venlafaxine (Effexor) Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Venlafaxine (Effexor). Running one of the largest drug safety studies in the world, eHealthMe is able to enable everyone to run personal clinical trial. Have you noticed any unwanted side effects since taking Effexor XR? Realize that for some users, Effexor is an immensely helpful anxiolytic, while for others (like myself), it may be nothing more than an ineffective nightmare. my paranoia is from cptsd. Its hard to be relaxed enough to fall asleep. Researchers Bose, Korotzer, and Gommoll (2008) documented the effects of Effexor XR and Lexapro for the treatment of generalized anxiety disorder. They recruited a large number of participants, each of which were diagnosed with generalized anxiety (based on DSM-IV criteria). The participants were set to receive either: Lexapro (10 to 20 mg per day), Effexor XR (75 to 225 mg per day), or a placebo (daily) â for a term of 8-weeks. first on 37.5mg and then 75mg + combo of welbutrin 150mg for the last couple months when i felt that i was starting to get paranoia again. A little too hyper and energetic with some agitation. All anxiolytic improvements were sustained for the entire 6 weeks of treatment, and in a longer study, for a span of 12 weeks. Although Effexor is already a well-established antidepressant, this meta-analysis provides evidence to support its usage as a monotherapy for cases of depression with concomitant anxiety. Dose-related elevations in blood pressure have been noted with venlafaxine. Lipov E and Kelzenberg Briana. If youâve tried Effexor XR for an anxiety disorder (or are currently taking it), share your experience in the comments section below. The ideas, procedures, and suggestions contained within this work are not intended as a substitute for consulting with a medical doctor. You can also subscribe without commenting. Overall ratings: 3.5/5 Effexor (Venlafaxine): This is considered the first SNRI (serotonin-norepinephrine reuptake inhibitor) antidepressant to ever get approval from the FDA. ... Intrusions of traumatic memories, hyperarousal, and symptoms of avoidance and psychological numbness are features of post-traumatic stress disorder (PTSD). Lost my career as a Television Producer and went on Disability -worked part time as a cashier but canât anymore. suicidal for years. Increased anxiety at dose of 225 mg and most likely even less. assessed the safety and efficacy of Effexor XR as a treatment for generalized anxiety disorder among older patients. They reviewed evidence from 5 placebo-controlled, double-blind, randomized, parallel-group, multicenter trials to determine Effexor XRâs safety and efficacy among 1,839 older individuals. Next post: Valerian For Anxiety Disorders, Previous post: Propranolol For Anxiety Disorders: A Nonselective Beta Blocker. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. However, talk therapy is generally recommended as a first-line intervention and most clinicians will recommend that pills be taken in ⦠1999: Once-daily venlafaxine extended release (XR) compared with fluoxetine in outpatients with depression and anxiety. -Maximum dose: ---Moderately depressed outpatients: 225 mg/day. To help others get a better idea of your situation, document how effective (subjectively) you perceive Effexor XR to be for anxiety (on a scale of 1 to 10) as well as whether you are taking it as a standalone treatment or as part of a medication cocktail. October 4, 2006 â Extended-release (ER) venlafaxine is beneficial for improving symptoms of posttraumatic stress disorder (PTSD) and depression, according to the results of a 6-month, placebo-controlled trial reported in the October issue of the Archives of General Psychiatry . 2004: Efficacy of Venlafaxine ER in patients with social anxiety disorder: a double-blind, placebo-controlled, parallel-group comparison with paroxetine. It is documented that up to 40% of individuals diagnosed with OCD derive insignificant therapeutic benefit from SSRIs. Although SSRIs are an effective first-line option, other pharmacological options are necessary to treat the 40% of non-responders. For this reason, researchers Hollander et al. All 24 participants were administered Effexor XR (once daily) for a period of 12 weeks. No additional pharmacological or behavioral interventions were implemented throughout the study. Measures of hoarding behavior were collected with the Saving Inventory-Revised (SI-R) and the UCLA Hoarding Severity Scale (UHSS); each assessment was administered before and after the 12-week trial. Some people report experiencing "brain shivers" or âbrain zapsâ when they are late taking their prescribed dose of Effexor.2 People often describe these sensations as a very brief, repetitive electric shock-like feeling that remains confined to the brain or head. Not only did it make me feel more depressed and suicidal, but it worsened my anxiety. I ended up with severe brain fog, hot flashes, depersonalization, and felt as if I was living in a bad dream. Between the temperature changes, the worsening of anxiety, and increasingly depressed mood â my experience with Effexor XR was nothing short of nightmarish. Clearly, not everyone taking Effexor XR has such an awful experience of adverse effects and/or exacerbation of anxiety – many people find it highly beneficial. This is a reivew of how effective Effexor (venlafaxine hydrochloride) is for Post-traumatic stress disorder and for what kind of people. Sertraline is also used to treat obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). Opioidergic effects: Newer evidence suggests that venlafaxine is an indirect opioid receptor modulator. In animal research, venlafaxine administration appeared to exhibit a dose-dependent analgesic effect, resulting in attenuation of pain responses. It is unclear as to what extent opioidergic neurotransmission is affected among humans taking Effexor, but it may contribute to an anxiolytic effect. Additionally, Effexor appears to effectively treat cases of major depression with comorbid anxiety as a monotherapy; this may be advantageous to administration of multiple drugs simultaneously. It is thought to have few interactions and is universally regarded as a âwell-toleratedâ anxiolytic. The anxiolytic efficacy of Effexor appears to be significant over a short-term (4 to 8 weeks) and over a long-term (up to 12-months). Completely lost who I was. Wyeth launched venlafaxine for the treatment of depression in the United States in early 1994 under the trade name Effexor. The reuptake inhibition of norepinephrine may increase a userâs neurophysiological arousal just enough to decreased anxiety associated with feeling âspaced outâ or overly relaxed. Since the norepinephrine increases generated by Effexor arenât significant when compared to serotonin, users are unlikely to feel overly-energetic or jittery. Although noradrenergic properties are unlikely to significantly contribute to anxiolytic effects of Effexor when compared to serotonergic properties, the combination of both may be helpful for certain cases of anxiety. Notify me of followup comments via e-mail. It was noted that in 2 randomized, placebo-controlled, double-blinded trials â Effexor demonstrated short-term and long-term efficacy for the treatment of PTSD symptoms. Due to the limited research of Effexor as a treatment for PTSD, it is unclear as to whether it can be considered therapeutically effective. That said, authors of this review hypothesize a therapeutic role of Effexor XR to mitigate severity of PTSD. Other drugs that have the same active ingredients (e.g. Maybe I could have kept it if there was a more pronounced opioid-mechanism… really sh*tty it got to this. -- ⦠(2002) assessed the efficacy of Effexor compared to clomipramine (a tricyclic antidepressant) for the treatment of OCD. For the trial, researchers recruited a total of 73 patients that had been diagnosed with OCD (based on DSM-IV criteria). Of the 73 participants, a total of 26 received Effexor (225-350 mg/day) and 47 received clomipramine (150-225 mg/day) for a duration of 12 weeks. In this case, PTSDâs more complex cousin, CPTSD, might be diagnosed. Lithium For Anxiety Disorders: An Unconventional, Underinvestigated Intervention.  They recruited 24 individuals diagnosed with hoarding disorder (based on DSM-5 criteria) for an open-label trial. It should be noted that, prior to this trial, all patients were free of psychiatric medications for at least 6 weeks. Venlafaxine (Effexor): 75 mg to 300 mg daily. 2007: Venlafaxine extended release (XR) in the treatment of panic disorder. Effexor (venlafaxine) is an antidepressant that is generally prescribed in an extended-release form as Effexor XR. It was known that Effexor XR is a safe, effective treatment for generalized anxiety disorder among adults, but safety and efficacy havenât been specifically investigated among older adults. An analysis published in 2002 by Katz et al.  I believe its noradrenergic mechanism worsened my anxiety by making me feel jittery and as if I wanted to crawl out of my skin. I felt it start working after about a week and really kick in after 3 weeks. Pharmacodynamically, it functions primarily as a serotonin-norepinephrine reuptake inhibitor (SNRI) and is understood to be the first-ever dual reuptake inhibitor approved by the FDA for the treatment of major depressive disorder. Results indicated that symptoms of hoarding disorder were significantly attenuated with administration of Effexor XR. Average scores on the SI-R decreased by 32% and average scores on the UHSS decreased by 36%. Of the 23 individuals that finished the study, 70% were thought to derive significant therapeutic benefit from Effexor XR. This provides preliminary evidence to suggest that Effexor XR may be a viable pharmaceutical for individuals with hoarding disorders, a subtype of anxiety disorder. It's normal to have upsetting memories, feel on edge, or have trouble sleeping after this type of event. Some medications are more notorious for this symptom than others. A large-scale trial conducted by Allgulander et al. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. ... Prozac or Effexor) may be prescribed. Individuals receiving the Paxil also experienced a significant reduction in symptoms of social anxiety as compared with the placebo â across both primary and secondary measures. There were no significant differences in anxiolytic benefit among those taking Effexor XR compared to those taking Paxil. Both Effexor XR and Paxil were considered safe, effective, and well-tolerated â providing additional evidence to support the usage of Effexor XR for social anxiety disorder. I’m assuming it will continue to dissipate as my body is still in the adjustment phase. Since Effexor modifies serotonergic transmission to nearly 30-times the extent of norepinephrine, it should be suspected that most of the anxiolytic benefit is attained via alterations of the serotonin system. Other SNRIs such as Cymbalta, Pristiq, and Fetzima are not typically effective for the treatment of anxiety disorders because they exhibit less significant targeting of serotonin relative to norepinephrine. As a result, these other agents are considered effective for depression, but may exacerbate some cases of anxiety. Results indicated that age of the patient didnât affect the efficacy of Effexor XR as a treatment for generalized anxiety disorders. Nearly 66% of patients were considered responders to Effexor XR, whereas only 41% responded to the placebo; these percentages are nearly identical to those seen in studies of younger adults. Researchers concluded that Effexor XR is safe and well-tolerated as a treatment for generalized anxiety disorder, regardless of a userâs age (e.g. eHealthMe is studying from 88,789 Effexor users. Results suggested that all individuals receiving the Effexor XR and Lexapro exhibited significantly reduced symptoms of generalized anxiety disorder after 8-weeks (as evidenced by the HAM-A). Researchers suggested that both treatments were effective and well-tolerated for the treatment of generalized anxiety disorder. However, fewer tolerability issues were reported among Lexapro users. Effexor (venlafaxine hydrochloride) is indicated for the treatment of major depressive disorder. This site uses Akismet to reduce spam. All matters regarding your health require medical supervision. A trial conducted by Rynn et al. Benzodiazepines act on the gammaâaminobutyric acid (GABA)âbenzodiazepine receptor complex and are associated with a reduction in anxiety. 2002: Venlafaxine versus clomipramine in the treatment of obsessive-compulsive disorder: a preliminary single-blind, 12-week, controlled study. Effexor (Venlafaxine) is a drug that was introduced in 1993 as a pharmaceutical antidepressant by Wyeth; its marketing rights are now owned by Pfizer. A study published by Il’ina (2009) examined the efficacy of venlafaxine among 30 individuals diagnosed with âanxious-depression.â Of the 30 individuals, 7 were male and 23 were female, and 24 were treated on an inpatient basis, while 6 were treated as outpatients. All patients received venlafaxine for an 8-week period at dosages ranging from 225 mg to 375 mg. The efficacy of Effexor in the treatment of major depressive disorder was established in 6-week controlled trials of adult outpatients whose diagnoses corresponded most closely to the DSM-III Post-traumatic stress disorder is found to be related to 1,236 drugs and 790 conditions by eHealthMe. 2002: Venlafaxine ER as a treatment for generalized anxiety disorder in older adults: pooled analysis of five randomized placebo-controlled clinical trials. Olmstead et al 2019. This chapter reviews pharmacotherapy for posttraumatic stress disorder (PTSD) and touches on the effects of medication on the brain. Still want to die. 18.75-75 mg/day; may increase to 150 mg/day after 4 weeks; doses up to 225 mg/day used. Upon comparison to SSRIs, tolerability of Effexor XR is considered similar. A few potentially unwanted noradrenergic side effects such as dry mouth, constipation, and hypertension â may occur among a subset of users. That said, it was concluded that Effexor XR was an effective, tolerable treatment for a myriad of anxiety disorders. Of the 320 participants, 157 received Effexor XR while the remaining 163 received a placebo for 8-weeks. Anxiety severity was measured based on 9 items from the Schedule For Affective Disorders and Schizophrenia for School-Age Children scale. Secondary measures included the Pediatric Anxiety Scale and Hamilton Anxiety Scale (HAM-A). Among the first investigations of Effexor XR as a treatment for anxiety was conducted in 1998 by Feighner, Entsuah, and McPherson. In this report, researchers analyzed the effects of Effexor XR (75-225 mg/day) in 2 randomized, double-blinded, placebo-controlled trials. Researchers specifically sought to determine how Effexor XR administration affected anxiety levels of those receiving it as a treatment for depression. In some cases, Effexor was better tolerated to already-approved agents and/or yielded greater improvement of anxious symptoms. It is also necessary to note that certain studies found Effexor to be faster-acting than SSRIs, providing quicker therapeutic benefit to patients by comparison. Moreover, many researchers speculate that its propensity to target both serotonin and norepinephrine reduces likelihood of adverse effects such as weight gain. A paper published in 2004 by Katzman discussed Effexor XR as a pharmacological intervention for the treatment of anxiety disorders. The author noted that Effexor XR exhibits unique pharmacodynamics in that it acts as a dual-reuptake inhibitor, simultaneously targeting both serotonin and norepinephrine. Furthermore, it was mentioned that Effexor XR appears to provide clinically significant anxiety reduction among those with various anxiety disorders â as evidenced by controlled trials.  Many psychiatric medications for anxiety disorders are are a neurochemical gamble. The sensation can be triggered by moving your eyes and is often accompanied by disorientation, tinnitus (ringing in the ears), vertigo, and/or lightheadedness. Measures were taken of mental state with various scales including the: CGI, HDRS, BDI, and HADS-21. Results indicated that a majority of patients responded well to venlafaxine administered at intermediate doses. Depressive symptoms, anxiety symptoms (especially somatic), as well as overall âmental stateâ â significantly improved for a majority of patients. This highlights the efficacy of Effexor in treating depression with comorbid anxiety. In the second study, significant reductions in anxiety were noted from weeks 1 to 8. Some adverse effects such as: dry mouth, dizziness, insomnia, nausea, and sleepiness were reported; leading to discontinuation in 11% of patients. That said, this report provides evidence to support the usage of Effexor XR (75-225 mg/day) to attenuate symptoms of anxiety among individuals with major depression. Others report the sensation spreads out to other parts of the body. (2004) analyzed the efficacy of Effexor, an SNRI as an alternative treatment for OCD. 1 year). Effexor is an antidepressant medication known as a serotonin-norepinephrine reuptake inhibitor. A report by Thase (2006) discussed the usage of Effexor XR as a treatment for anxiety disorders. In the report, it was noted that following the introduction of an XR (extended-release) format of venlafaxine in 1997, the drug received approval as a treatment for several subtypes of anxiety disorders including: generalized anxiety disorder (GAD), panic disorder, and social phobia. Thase highlighted evidence to suggest that Effexor XR was also likely effective as a treatment for PTSD and OCD. To determine efficacy of pharmacological interventions, researchers measured severity of depression and anxiety throughout the trial with various scales such as the: Hamilton Rating Scale for Depression (HAM-D), Hamilton Rating Scale for Anxiety (HAM-A), and Clinical Global Impressions scale (CGI-S). Results indicated that Effexor XR and Prozac were superior to the placebo for the treatment of depression (as evidenced by HAM-D scores). Improvements in depressive symptoms began at week 2 and were maintained throughout the entirety of the 12-week trial duration.
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